Douglas Borchman, Ph.D.

Professor, Department of Ophthalmology and Visual Sciences

Research Faculty

CONTACT INFORMATION:

301 E. Muhammad Ali Boulevard, Louisville KY 40202
Telephone: 502-852-7435
E-mail: Borchman@louisville.edu

EDUCATION:
B.S.:

Wayne State University, Detroit, Michigan, Chemistry (Biochemsitry 1972-1977

Ph.D.:

Wayne State University, Detroit, Michigan, Chemistry (Biochemistry) 1979-1984 (with minor in Biology)

FELLOWSHIPS:

Mt Sinai Hospital, New York, New York, Post Doctoral Fellowship, Physiology and Biophysics 1984-1986

RESEARCH INTERESTS:

As a biophysicist, I am equally fascinated by how the human lens can remain clear for decades, as by the factors which cause that clarity to diminish over time. This fascination has led me to explore how the composition, structure and function of membrane lipids contribute to the light scattering with age and cataracts.

The techniques and experience gained from my studies of lens lipids enabled me to study how derangement of tear oils cause dry eye symptoms. In collaboration with Dr. Foulks and Yappert I am using my spectroscopic background in biophysics to follow compositional and conformational changes in tear lipids with age and meibomian gland disease and to diagnose and elucidate the causes of dry eye symptoms.

PUBLICATIONS:
  1. Borchman D, Foulks GN, Yappert MC, Kakar S, Podoll N, Rychwalski P, Schwietz E.  Physical Changes in Human Meibum with Age as Measured by Infrared Spectroscopy.  Ophthalmic Res. 44:34-42, 2010.  PMID: 20160464.
  2. Estrada R, Puppato A, Borchman D, Yappert MC. Re-evaluation of the phospholipid composition in membranes of adult human lenses by 31-P NMR and MALDI-MS.  Biochim. Biophys. Acta-Biomembranes.  1798:303–311, 2010.  PMID: 19925778.
  3. Foulks GN, Borchman D, Yappert MC, Sung-Hye K, McKay JW.  Topical Azithromycin Therapy of Meibomian Gland Dysfunction: Clinical response and lipid alterations.  Cornea, 29:781-788, 2010.  PMID: 20489573.
  4. Foulks GN, Borchman D.  Meibomian gland dysfunction:the past, the present, the future.  Eye Contact Lens.  36:249-53, 2010.  PMID: 20724853.
  5. Borchman D. and Yappert M.C.  Lipids and the Ocular Lens.  J. Lipid Res. 51:2473-88, 2010.  PMID: 20407021.
  6. Borchman D, Foulks GN, Yappert MC.  Confirmation of changes in human meibum lipid infrared spectra with age using principal component analysis.  Curr. Eye Res. 35:778-86, 2010.  PMID: 20795859.
  7. Borchman D, Foulks GN, Yappert MC.  Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis. Exp Eye Res. 91:246-56, 2010.  PMID: 20546726.
  8. Green-Church KB, Butovich I, Willcox M, Borchman D, Paulsen F, Barabino S, Glasgow B.  Meibomian Gland Contribution to the Tear Film.  In:  The Report of the International Workshop on Meibomian Gland Dysfunction.  Invest. Ophthalmol. Vis. Sci. 52:1979-1993, 2011.  PMID: 21398284.
  9. Borchman D, Foulks GN, Yappert MC, Bell J, Wells E, Neravetla S, Greenstone V.  Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction.  Invest. Ophthalmol. Vis. Sci. 52:3805-17, 2011.  PMID: 21398284.
  10. Ashraf Z, Pasha U, Greenstone V, Akbar J, Apenbrinck E, Foulks GN, Borchman D. Quantification of Human Sebum on Skin and Human Meibum on the Eye Lid margin using Sebum Tape, Spectroscopy and Chemical Analysis.  Curr Eye Res. 36:553-62, 2011.  PMID: 21591865.
  11. Shresthu RK, Borchman D, Foulks GN, Yappert MC.  Analysis of the Composition of Lipid in Human Meibum from Normal Infants, Children, Adolescents, Adults and Adults with Meibomian Gland Dysfunction using 1H-NMR Spectroscopy.  Invest Ophthalmol Vis Sci.  52:7350-7358, 2011.  PMID: 2184942.
  12. Borchman D, Foulks GN., Yappert MC, Milliner SE.  Differences in Human Meibum Lipid Composition with Meibomian Gland Dysfunction using NMR and Principal Component Analysis. Invest Ophthalmol Vis Sci.  53:337-47, 2012.  PMID: 22131391.
  13. Borchman D, Foulks GN., Yappert MC, Milliner SE.  Changes in Human Meibum Lipid Composition with Age Using NMR Spectroscopy.  Invest Ophthalmol Vis Sci.  53:475-482, 2012. PMID: 22169100.
  14. Faheem S, Kim S, Nguyen J, Neravetla S, Ball M, Foulks GN, Yappert MC, Borchman D.  Wax-Tear and Meibum Protein, Wax-β-carotene Interactions in Vitro Using Infrared Spectroscopy.  Exp Eye Res 100:32-9, 2012.  PMID: 22564968.
  15. Vishnubhatla S, Foulks GN, Borchman D. Contact Lenses and the Rate of Evaporation Measured in Vitro; the Influence of Wear, Squalene and Wax.  Contact Lens Anterior Eye, 35:277– 281, 2012.  PMID: 22906863.
  16. Foulks GN, Borchman D, Yappert MC, Kakar S.  Topical Azithromycin and Oral Doxycycline Therapy of Meibomian Gland Dysfunction: A Comparative Clinical and Spectroscopic Pilot Study.  Cornea. 32:44-53, 2013.  PMID: 2266858.
  17. Borchman D, Yappert MC, Milliner S, Duran D, Cox GW, Smith RJ, Bhola R.  13C and 1H NMR Ester Region Resonance Assignments and the Composition of Human Infant and Child Meibum.  Exp Eye Res, 112:151-159, 2013.  PMID: 2364409.
  18. Borchman D, Yappert MC, Milliner S, Bhola R.  Confirmation of squalene in human eye lid lipid by heteronuclear single quantum correlation spectroscopy.  Lipids. 48:1269-1277, 2013.  PMID:  24081494.
  19. Mudgil P, Borchman D, Yappert MC,  Duran D, Cox GW, Smith RJ, Bhola R, Dennis GR, Whitehall JS.  Human Meibum Saturation and Lipid Order.  Exp Eye Res 116C:79-85, 2013.  PMID: 23973715.
  20. Borchman D.  From the Bench to the Bedside.  Infrared Spectroscopy and the Diagnosis and Treatment of Dry Eye and Cataracts. Spectroscopy. 29: 38-52, 2014.
  21. Hunter M, Bhola,R, Yappert MC, Borchman D, Gerlach D. Pilot Study of the Influence of Eyeliner Cosmetics on the Molecular Structure of Human Meibum. Ophthalmic Res. Ophthalmic Res. 53:131-5, 2015. PMID: 25720840.
  22. Ivanova S, Borchman D, Yappert MC, Tonchev V, Yokoi N, Georgiev G. Surface properties of squalene/meibum films and NMR confirmation of squalene in tears. International J Mol Sci. 9;16:21813-31, 2015. PMID: 26370992.
  23. Borchman D. Does the tear film lipid layer inhibit the rate of evaporation of tears? EC Ophthalmology, 3:251-253, 2015.
  24. Mudgil, P, Borchman, D,  Gerlach, D, Yappert MC. Sebum/Meibum Surface Film Interactions and Phase Transitional Differences. Investigative Ophthalmol Vis Sci. 57:2401-2411, 2016. PMID: 27145473.
  25. Sledge SM, Borchman D, Oliver A, Michael H, Dennis EK, Gerlach D, Bhola R, Stephen E. Evaporation and Hydrocarbon Chain Conformation of Surface Lipid Films. Ocul Surf. In Press 2016.