Clinical Trials in the University of Louisville Department of Ophthalmology & Visual Sciences

Advancing Our Understanding of Eye Diseases and How to Treat Them

Clinical trials in the University of Louisville Department of Ophthalmology & Visual Sciences are offering patients and doctors the opportunity to participate in potentially groundbreaking therapies and procedures and advance the field of ophthalmological research. We’re assessing new drugs for approval. Evaluating new instruments and techniques. We’re doing the clinical trials that will change the way doctors view and treat eye diseases in the future.

The University of Louisville’s status as an academic medical center means we are commonly involved in multi-center clinical trials often sponsored by the National Institutes of Health. The Department of Ophthalmology’s specialized equipment and photographic capabilities give us the resources to participate in difficult trials that require very high technical evaluation.

We are always looking for the help of volunteer patients interested in advancing the understanding of eye diseases. The department regularly has several trials in progress.

Current Open Ophthalmology Trials at the University of Louisville

Pediatric Glaucoma Study - Allergan

Sponsored by Allergan Pharmacuticals. Evaluating the safety and IOP-lowering effect of once-daily bimatoprost PF compared to twice-daily timolol in pediatric patients with glaucoma. Ongoing.

Growth and Retinopathy of Prematurity - G-ROP

Sponsored by the National Eye Institute. Retrospective study to develop a prognostic model that includes postnatal weight gain, birth weight, and gestational age at birth to predict infants who are likely to develop severe ROP. Ongoing.

Comparison of Age-related Macular Degeneration Treatment Trials: Lucentis-Avastin Trial

pLucentis-Avastin Trial. Sponsored by the National Eye Institute (NEI). Compares two drug treatments for neovascular “wet” AMD for their effects on vision and for safety. No longer enrolling patients.

Study of the Pathogenesis of Retinal Degeneration

Sponsored by the Robert Rounsavall, Jr. Family Foundation. Examining the possibility that genetic patterns exist among people with Age-related Macular Degeneration (AMD) and other types of retinal degeneration, opening the possibility of finding genes connected with those diseases, their exact causes, and perhaps the ability to prevent some types of retinal degeneration altogether. Ongoing.

Telemedicine Approaches to Evaluating Acute-phase Retinopathy of Prematurity – e-ROP

Sponsored by the National Eye Institute. Evaluating a remote imaging system for babies that are at risk for developing sight-threatening ROP and are in need of a diagnostic evaluation by an ophthalmologist experienced in ROP. Ongoing.

MaculaRisk Genetic Test (Age-related Macular Degeneration Genetic Test)

Identifying individuals who have inherited the disease-causing genes for Age-related Macular Degeneration. Ongoing.

For more information about participating in research at the University of Louisville, please CLICK HERE. You can also contact our Clinical Research Coordinator, Michelle Bottoroff, at 502-852-7387 or email mlbott03@louisville.edu.

Understanding Clinical Trials

Choosing to participate in a clinical trial is an important decision. It’s always helpful to discuss your potential participation with your physician, family members, and friends to determine what is right for you.

Clinical trials can be the best way for participants to:

  • Actively play a role in the healthcare they receive
  • Take part in the latest research treatments before they are widely available to other patients
  • Contribute to medical research that may help others

Too often, the myths about clinical trials get more attention than the facts. Here’s the truth behind some of the most common misconceptions:

  • Clinical trials are not just an option used as a last resort
  • Trial participants are not “guinea pigs” for testing drugs
  • Clinical trials are not just for sick patients—they’re for healthy patients, too

It’s important to note that the ethical and legal codes that apply to medical practice apply to clinical trials as well. Also, clinical trials in the University of Louisville Department of Ophthalmology & Visual Sciences are carefully regulated with built in safeguards to protect participants.

If you have further questions about clinical trials, please visit www.ClinicalTrials.gov, a service of the U.S. National Institutes of Health. There you’ll find extensive information about the clinical trials process, including more on the benefits and potential risks.